PCR and PGx testing

PCR and PGx testing service

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All our direct customer tests are sold as home test kits. Please visit our customer-facing company website Test2Go for more information.

All-in-one testing provider

Our end-to-end testing service includes sample collection kits, door-to-door courier, testing, and integrated reporting for pathogen detection and pharmacogenomics. Real-Time Quantitative PCR monitors and measures the amplification of a specific genetic sequence using fluorescent dyes. RT-qPCR is a highly flexible technique which can be customised with a variety of assays to suit many functions.

    • Diagnostic – Rapidly detects the presence of micro-organisms including pathogens.
    • Gene Expression – Analyses the RNA present in cells to measure gene expression.
    • Genotyping – can distinguish single-nucleotide polymorphisms to measure genetic variation including detecting specific alleles.

Fast and flexible service for clinical trials

The CYP2D6 gene encodes the Cytochrome P450 2D6 enzyme, which is vital for the metabolism of around 25% of all prescription drugs. The gene is highly polymorphic, with many alleles resulting in reduced, or completely eliminated, enzyme activity. Poor metabolizers are defined as people having genotypes that result in no enzyme activity, who make up around 5-10% of the global population. These people are at higher risk of adverse reactions from drugs which rely on the CYP2D6 metabolic pathway, so it is important to exclude them from clinical trials which involve these drugs.

    • Our CYP2D6 assay covers tier 1 and tier 2 alleles recommended by the Association of Molecular Pathologists for clinical CYP2D6 testing.
    • Fast turnaround of just 2-3 working days with no minimum batch size keeps subject screening moving smoothly.
    • Dedicated client portal for secure sample registration and result reporting.
    • Door-to-door courier with refrigerated packaging provided.

PCR machine used for PCR and PGx testing

Accurate and reliable

Our dedicated molecular biology lab offers a complete high-throughput solution from sample processing, nucleic acid extraction and purification to RT-qPCR. We use the latest state-of-the-art automated equipment to deliver the most accurate and sensitive PCR and PGx testing results.

      • Kingfisher Flex extraction system for automated nucleic acid extraction and purification.
      • QuantStudio 5 real-time PCR system for analysis of up to 384-well plates.

Every assay we offer is verified by us using traceable reference standards before being launched. PCR test kits used for SARS-CoV-2 testing have been verified by Hampshire Hospitals NHS Foundation Trust and Public Health England. They have been proven to correctly identify all positive and negative samples tested.

Our laboratory also offers Next Generation Sequencing for whole genome sequencing, species identification, and shotgun metagenomics.

EM Analytical

Providing advanced testing and characterisation services